Polioencephalomalacia associated with closantel overdosage in a goat
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منابع مشابه
Polioencephalomalacia associated with closantel overdosage in a goat.
This report describes clinical and pathological findings associated with closantel (a halogenated salicylanilide anthelmintic) overdosage in a 3-year-old goat. The clinical signs included blindness, incoordination, ataxia, depression of the palpebral and pupillary reflexes, and recumbency. No gross lesions were noted in tissue or organs at necropsy, but microscopic lesions were seen in nervous ...
متن کاملClinical communication — Kliniese mededeling Polioencephalomalacia associated with closantel overdosage in a goat
INTRODUCTION The halogenated salicylanilides are a group of compounds developed mainly for their antiparasitic activity in animals. Closantel and rafoxanide, which represent the most important drugs in this group, are used extensively for the control of Haemonchus spp. and Fasciola spp. infestations in sheep and cattle and Oestrus ovis in sheep in many parts of the world. Clinical signs of clos...
متن کاملMyelin vacuolation, optic neuropathy and retinal degeneration after closantel overdosage in sheep and in a goat.
Toxicity of closantel, a halogenated salicylanilide anthelmintic, is described in 11 sheep and a goat, humanely killed 4-70 days after accidental overdosage. Status spongiosis of the cerebrum and cerebellum was present, its severity decreasing with time after treatment. Ultrastructurally, vacuoles in the cerebral white matter were seen to be intramyelinic due to splitting of myelin lamellae at ...
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ژورنال
عنوان ژورنال: Journal of the South African Veterinary Association
سال: 2010
ISSN: 2224-9435,1019-9128
DOI: 10.4102/jsava.v81i2.117